Hyperbaric oxygen is oxygen used as a pharmaceutical drug. The dosage and absorption is regulated by the pressure in the chamber and the established protocols of the Undersea and Hyperbaric
Medicine Society. As with any drug, too small a dose will provide no therapeutic value and too high a dose will produce toxicity. Hyperbaric oxygen is delivered in either a single person (monoplace) chamber or a multiperson (multiplace) chamber. Each type of chamber is capable of meeting the parameters of the radiation tissue elective surgery protocol and the osteoradionecrosis treatment protocol. The 100% oxygen breathed at 2.4 ATA dissolves oxygen in physical solution in interstitial tissues and blood.
This oxygenation of tissues outside the hemoglobin delivery system is able to generate enhanced oxygen gradients throughout the irradiated tissue and especially between the
Irradiated and no irradiated tissue .This permits wound healing macrophages to migrate into the area and secrete several cytokines, including vascular endothelial growth factor (VEGF) that stimulate capillary angiogenesis and fibroplasia .
The result is that the three tissue that begins at about 30% of normal vascularity realizes an increase to about 75% of normal vascularity. The protocol of 20 HBO sessions prior to elective surgery in irradiated tissue followed by10 sessions after surgery creates this angiogenesis, which is permanent. Therefore, repeated or follow-up surgeries in the irradiated area would not require repeated HBO protocols.
Hyperbaric Oxygen and Cancer
The most common application of HBO therapy for oral and maxillofacial indications is in irradiated Patients with a history of cancer, particularly squamous cell carcinoma. Some clinicians have been concerned about the potential of HBO to stimulate dormant cancer cells or accelerate growth of existing, unrecognized cancers. However, to date, several well.performed animal studies and one human trial have shown no promotion of cancer growth or emergence of new primary carcinomas in patients who have undergone HBO therapy. This is most likely because cancers are autonomous Mutating cell populations expressing abnormal genes. They proliferate as facultative anaerobes by producing their own set of cytokines and growth factors independently of normal growth factors.
Hyperbaric oxygen works through wound macrophages, not on epithelial cells, and causes these Macrophages to express normal gene functions related to angiogenesis (VEGF) and collagen synthesis (BFGF). For the clinician and the patient, it is important to understand that HBO does not expose one to a higher risk of recurrent or new primary carcinomas.
Hyperbaric Oxygen and Cancer
The most common application of HBO therapy for oral and maxillofacial indications is in irradiated Patients with a history of cancer, particularly squamous cell carcinoma. Some clinicians have been concerned about the potential of HBO to stimulate dormant cancer cells or accelerate growth of existing, unrecognized cancers. However, to date, several well.performed animal studies and one human trial have shown no promotion of cancer growth or emergence of new primary carcinomas in patients who have undergone HBO therapy. This is most likely because cancers are autonomous Mutating cell populations expressing abnormal genes. They proliferate as facultative anaerobes by producing their own set of cytokines and growth factors independently of normal growth factors.
Hyperbaric oxygen works through wound macrophages, not on epithelial cells, and causes these Macrophages to express normal gene functions related to angiogenesis (VEGF) and collagen synthesis (BFGF). For the clinician and the patient, it is important to understand that HBO does not expose one to a higher risk of recurrent or new primary carcinomas.
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