Periostat is a medication against advanced chronic periodontitis, produced by CollaGenex Pharmaceuticals. The active compound is the antibiotic doxycycline, 20mg of which is contained in each tablet of Periostat.
Mechanism of Action
Doxycycline has been shown to inhibit collagenase activity in vitro. Additional studies have shown that doxycycline reduces the elevated collagenase activity in the gingival crevicular fluid of patients with adult periodontitis.
Microbiology
Doxycycline is a member of the tetracycline class of antibiotics. The dosage of doxycycline achieved with this product during administration is well below the concentration required to inhibit microorganisms commonly associated with adult periodontitis. Clinical studies with this product demonstrated no effect on total anaerobic and facultative bacteria in plaque samples from patients administered this dose regimen for 9 to 18 months. This product should not be used for reducing the numbers of or eliminating those microorganisms associated with periodontitis.
Indicated for use as an adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depths
Periostat is available as a tablet(20mg) to be taken orally two times a day (about an hour before, or two hours after meals). Should be taken with plenty of fluids.
Typical treatments range from 3months to 12months.
Clinical studies have shown that the use of Periostat, along with scaling/root planning is more effective at regaining attachment level, than treatment with scaling/root planning alone.
Periostat is the first and only therapeutic agent designed to modulate the host response and helps to slow the progression of periodontal disease.
Periostat should be used when traditional scaling/root planning treatments alone are ineffective, but before surgery is indicated.
Periostat is not an antibiotic- the low dosages of periostat have no detectable effect on bacteria.
Periostat should not be used with children, expecting mothers, nursing mothers, or anyone with a tetracycline hypersensitivity.
Periostat may cause hypersensitivity to sunlight
No reports of tooth staining
May reduce the effect of BCPs
Periostat is contraindicated for persons with tetracycline hypersensitivity, pregnant mothers, nursing mothers and children.
Periostat is used cautionly with persons susceptible for developing candidiasis and superinfection.
Mechanism of Action
Doxycycline has been shown to inhibit collagenase activity in vitro. Additional studies have shown that doxycycline reduces the elevated collagenase activity in the gingival crevicular fluid of patients with adult periodontitis.
Microbiology
Doxycycline is a member of the tetracycline class of antibiotics. The dosage of doxycycline achieved with this product during administration is well below the concentration required to inhibit microorganisms commonly associated with adult periodontitis. Clinical studies with this product demonstrated no effect on total anaerobic and facultative bacteria in plaque samples from patients administered this dose regimen for 9 to 18 months. This product should not be used for reducing the numbers of or eliminating those microorganisms associated with periodontitis.
Indicated for use as an adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depths
Periostat is available as a tablet(20mg) to be taken orally two times a day (about an hour before, or two hours after meals). Should be taken with plenty of fluids.
Typical treatments range from 3months to 12months.
Clinical studies have shown that the use of Periostat, along with scaling/root planning is more effective at regaining attachment level, than treatment with scaling/root planning alone.
Periostat is the first and only therapeutic agent designed to modulate the host response and helps to slow the progression of periodontal disease.
Periostat should be used when traditional scaling/root planning treatments alone are ineffective, but before surgery is indicated.
Periostat is not an antibiotic- the low dosages of periostat have no detectable effect on bacteria.
Periostat should not be used with children, expecting mothers, nursing mothers, or anyone with a tetracycline hypersensitivity.
Periostat may cause hypersensitivity to sunlight
No reports of tooth staining
May reduce the effect of BCPs
Periostat is contraindicated for persons with tetracycline hypersensitivity, pregnant mothers, nursing mothers and children.
Periostat is used cautionly with persons susceptible for developing candidiasis and superinfection.
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